Diphosphine Bioconjugates via Pt(0)-Catalyzed Hydrophosphination. A Versatile Chelator Platform for Technetium-99m and Rhenium-188 Radiolabeling of Biomolecules.

ABSTRACT: The ability to append targeting biomolecules to chelators that efficiently coordinate to the diagnostic imaging radionuclide, ^99mTc, and the therapeutic radionuclide, ¹⁸⁸Re, can potentially enable receptor-targeted "theranostic" treatment of disease. Here we show that Pt(0)-catalyzed hydrophosphination reactions are well-suited to the derivatization of diphosphines with biomolecular moieties enabling the efficient synthesis of ligands of the type Ph₂PCH₂CH₂P(CH₂CH₂-Glc)₂ (L, where Glc = a glucose moiety) using the readily accessible Ph₂PCH₂CH₂PH₂ and acryl derivatives. It is shown that hydrophosphination of an acrylate derivative of a deprotected glucos

SUBMITTER: Nuttall RE 

PROVIDER: S-EPMC10731653 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature