Role of polygenic risk scores in the association between chronotype and health risk behaviors.

ABSTRACT:

Background

This study explores the association between chronotypes and adolescent health risk behaviors (HRBs) by testing how genetic background moderates these associations and clarifies the influence of chronotypes and polygenic risk score (PRS) on adolescent HRBs.

Methods

Using VOS-viewer software to select the corresponding data, this study used knowledge domain mapping to identify and develop the research direction with respect to adolescent risk factor type. Next, DNA samples from 264 students were collected for low-depth whole-genome sequencing. The sequencing detected HRB risk loci, 49 single nucleotide polymorphisms based to significant SNP. Subsequently, PRSs were assessed and divided into low, moderate, and high genetic risk according to the tertiles and chronotyp

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10731716 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature