Early insulin resistance in normoglycemic low-risk individuals is associated with subclinical atherosclerosis.

ABSTRACT:

Background

Elevated glycated hemoglobin (HbA1c) is associated with a higher burden of subclinical atherosclerosis (SA). However, the association with SA of earlier insulin resistance markers is poorly understood. The study assessed the association between the homeostatic model assessment of insulin resistance index (HOMA-IR) and SA in addition to the effect of cardiovascular risk factors (CVRFs) in individuals with normal HbA1c.

Methods

A cohort of 3,741 middle-aged individuals from the Progression of Early Subclinical Atherosclerosis (PESA) study with basal HbA1c < 6.0% (< 42 mmol/mol) and no known CV disease underwent extensive imaging (multiterritorial vascular ultrasound and coronary artery calcium score, CACS) to assess the presence, burden, and extent of SA.

Results

SUBMITTER: Iglesies-Grau J 

PROVIDER: S-EPMC10731750 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature