Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson's disease.

ABSTRACT:

Background

Untargeted high-resolution metabolomic profiling provides simultaneous measurement of thousands of metabolites. Metabolic networks based on these data can help uncover disease-related perturbations across interconnected pathways.

Objective

Identify metabolic disturbances associated with Parkinson's disease (PD) in two population-based studies using untargeted metabolomics.

Methods

We performed a metabolome-wide association study (MWAS) of PD using serum-based untargeted metabolomics data derived from liquid chromatography with high-resolution mass spectrometry (LC-HRMS) using two distinct population-based case-control populations. We also combined our results with a previous publication of 34 metabolites linked to PD in a large-scale, untargeted MWAS to ass

SUBMITTER: Paul KC 

PROVIDER: S-EPMC10731845 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature