Comparison of Outcomes in Neonates Receiving Cefepime or Ceftazidime.

ABSTRACT:

Objectives

Cefepime and ceftazidime are alternatives to cefotaxime for management of Gram-negative infections in neonates. The objective was to evaluate neonatal outcomes when receiving cefepime or ceftazidime.

Methods

This was a single center, retrospective analysis of neonates exposed to at least 24 hours of cefepime or ceftazidime between June 1, 2018, and June 1, 2021. The primary outcome was incidence of culture-positive, late-onset sepsis after initial exposure. Secondary outcomes included culture-negative, respiratory, urinary tract, and resistant infections; necrotizing enterocolitis; length of stay; age at discharge; mortality; and adverse effects.

Results

A total of 105 neonates were included (cefepime, n = 50; ceftazidime, n = 55). Baseline characteristics

SUBMITTER: Ngo S 

PROVIDER: S-EPMC10731927 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature