Proton Pump Inhibitors Modulate Gene Expression Profile in Esophageal Mucosa and Microbiome.

ABSTRACT:

Objective

Proton pump inhibitors (PPIs) are commonly used to manage children with upper gastrointestinal symptoms and without a formal diagnosis. We investigated the effect of PPIs on esophageal mucosal transcriptome and active microbiota in children with normal esophagi. Furthermore, we examined whether the differences in host esophageal mucosal gene expression were driven by an underlying esophageal epithelial cell type composition.

Methods

Using metatranscriptomics, the host transcriptional and active microbial profiles were captured from 17 esophageal biopsy samples (PPI naïve [PPI-], n = 7; PPI exposed [PPI+], n = 10) collected from children without any endoscopic and histologic abnormalities in their esophagus (normal esophagus). Deconvolution computational analysis wa

SUBMITTER: Rajagopala SV 

PROVIDER: S-EPMC10731942 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature