Evaluation of the Use of Naltrexone for Cholestatic Pruritus.

ABSTRACT:

Objective

Pruritus is a common symptom of liver disease, managed with various medications including opioid antagonists like naltrexone. Current literature surrounding the safety and efficacy of naltrexone for cholestatic pruritus is limited. Our objective was to describe naltrexone prescribing practices for cholestatic pruritus.

Methods

We conducted a single-center, retrospective review of inpatients who received naltrexone for cholestatic pruritus. We gathered information on naltrexone dosing, frequency, dose adjustments, duration, elevations in liver function tests (LFTs), and use of additional antipruritic agents.

Results

Thirty-nine patients and 122 dosing regimens were included for analysis. Most patients were male (56.4%) with a median age of 6.32 years (range,

SUBMITTER: Sweigart AJ 

PROVIDER: S-EPMC10731951 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature