Brain-gut microbiome profile of neuroticism predicts food addiction in obesity: A transdiagnostic approach.

ABSTRACT: Neuroticism is one of the most robust risk factors for addictive behaviors including food addiction (a key contributor to obesity), although the associated mechanisms are not well understood. A transdiagnostic approach was used to identify the neuroticism-related neuropsychological and gut metabolomic patterns associated with food addiction. Predictive modeling of neuroticism was implemented using multimodal features (23 clinical, 13,531 resting-state functional connectivity (rsFC), 336 gut metabolites) in 114 high body mass index (BMI ≥25 kg/m²) (cross-sectional) participants. Gradient boosting machine and logistic regression models were used to evaluate classification performance for food addiction. Neuroticism was significantly associated with food addiction (P < 0.001). Neur

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10731989 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature