The versatility of the putative transient receptor potential ion channels in regulating the calcium signaling in Aspergillus nidulans.

ABSTRACT:

Importance

Transient receptor potential (TRP) ion channels are evolutionarily conserved integral membrane proteins with non-selective ion permeability, and they are widely distributed in mammals and single-cell yeast and serve as crucial mediators of sensory signals. However, the relevant information concerning TRP channels in Aspergillus nidulans remains inadequately understood. In this study, by gene deletion, green fluorescent protein tagging, and cytosolic Ca²⁺ transient monitoring techniques, the biological functions of three potential TRP channels (TrpA, TrpB, and TrpC) have been explored for which they play distinct and multiple roles in hyphal growth, conidiation, responsiveness to external stress, and regulation of intracellular Ca²⁺ homeostasi

SUBMITTER: Wang H 

PROVIDER: S-EPMC10732042 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature