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The impact of three carbapenems at a single-day dose on intestinal colonization resistance against carbapenem-resistant Klebsiella pneumoniae.

ABSTRACT:

Importance

The intestinal colonization of carbapenem-resistant Klebsiella pneumoniae (CRKP) is an important source of clinical infection. Our research showed that even single-day dose use of carbapenems caused CRKP colonization and continuous bacterial shedding, which reminds clinical doctors to prescribe carbapenems cautiously. Whenever possible, ertapenem should be the preferred choice over other carbapenems especially when the identified or highly suspected pathogens can be effectively targeted by ertapenem.

SUBMITTER: Kuang H

PROVIDER: S-EPMC10732052 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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The impact of three carbapenems at a single-day dose on intestinal colonization resistance against carbapenem-resistant <i>Klebsiella pneumoniae</i>.

Kuang Huan H Yang Yongqiang Y Luo Huan H Lv Xiaoju X

mSphere 20231127 6

<h4>Importance</h4>The intestinal colonization of carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) is an important source of clinical infection. Our research showed that even single-day dose use of carbapenems caused CRKP colonization and continuous bacterial shedding, which reminds clinical doctors to prescribe carbapenems cautiously. Whenever possible, ertapenem should be the preferred choice over other carbapenems especially when the identified or highly suspected pathogens can be eff ...[more]

PMID: 38009993

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