Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages.

ABSTRACT: SUMMARYMethicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful lineage has been replaced by a more fit and better adapted lineage. Selection pressures in both hospital and community settings are not uniform across the globe, which has resulted in geographically distinct epidemiology. This review focuses on the mechanisms that trigger the establishment and maintenance of current, dominant MRSA lineages across the globe. While the important role of antibiotic resistance will be mentioned throughout, factors which influence the capacity of S. aureus to colonize and cause disease within a host will be the primary focus of this review. We show that while MRSA

SUBMITTER: Jiang J-H 

PROVIDER: S-EPMC10732075 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature