Effects of skin tone on photoacoustic imaging and oximetry.

ABSTRACT:

Significance

Photoacoustic imaging (PAI) provides contrast based on the concentration of optical absorbers in tissue, enabling the assessment of functional physiological parameters such as blood oxygen saturation (sO2). Recent evidence suggests that variation in melanin levels in the epidermis leads to measurement biases in optical technologies, which could potentially limit the application of these biomarkers in diverse populations.

Aim

To examine the effects of skin melanin pigmentation on PAI and oximetry.

Approach

We evaluated the effects of skin tone in PAI using a computational skin model, two-layer melanin-containing tissue-mimicking phantoms, and mice of a consistent genetic background with varying pigmentations. The computational skin model was validated by s

SUBMITTER: Else TR 

PROVIDER: S-EPMC10732256 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature