Pharmacogenetics of weight gain following switch from efavirenz- to integrase inhibitor-containing regimens.

ABSTRACT:

Background

Excessive weight gain affects some persons with HIV after switching to integrase strand transfer inhibitor (INSTI)-containing antiretroviral therapy (ART). We studied associations between CYP2B6 genotype and weight gain after ART switch among ACTG A5001 and A5322 participants.

Methods

Eligible participants switched from efavirenz- to INSTI-containing ART, had genotype data, and had weight data at least once from 4 weeks to 2 years post-switch. Multivariable linear mixed effects models adjusted for race/ethnicity, CD4, age, BMI and INSTI type assessed relationships between CYP2B6 genotype and estimated differences in weight change.

Results

A total of 159 eligible participants switched ART from 2007 to 2019, of whom 138 had plasma HIV-1 RNA < 200 copies/mL (6

SUBMITTER: Wu K 

PROVIDER: S-EPMC10732300 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature