Parkinson Disease Genetics Extended to African and Hispanic Ancestries in the VA Million Veteran Program.

ABSTRACT:

Background and objectives

Nearly all genetic analyses of Parkinson disease (PD) have been in populations of European ancestry. We sought to test the ability of a machine learning method to extract accurate PD diagnoses from an electronic medical record (EMR) system, to see whether genetic variants identified in European populations generalize to individuals of African and Hispanic ancestries, and to compare the rates of PD across ancestries.

Methods

A machine learning method using natural language processing was applied to EMRs of US veterans participating in the VA Million Veteran Program (MVP) to identify individuals with PD. These putative cases were vetted via blind chart review by a movement disorder specialist. A polygenic risk score (PRS) of 90 established genetic var

SUBMITTER: Pankratz N 

PROVIDER: S-EPMC10732342 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature