Image-localized biopsy mapping of brain tumor heterogeneity: A single-center study protocol.

ABSTRACT: Brain cancers pose a novel set of difficulties due to the limited accessibility of human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet the mapping between MRI features and underlying biology remains ambiguous. Standard (clinical) tissue sampling fails to capture the full heterogeneity of the disease. Biopsies are required to obtain a pathological diagnosis and are predominantly taken from the tumor core, which often has different traits to the surrounding invasive tumor that typically leads to recurrent disease. One approach to solving this issue is to characterize the spatial heterogeneity of molecular, genetic, and cellular features of glioma through the intraoperative collection of multiple image-localized biopsy samples p

SUBMITTER: Urcuyo JC 

PROVIDER: S-EPMC10732423 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature