An In Vitro Characterization of a PCL-Fibrin Scaffold for Myocardial Repair.

ABSTRACT: Each year in the United States approximately 10,000 babies are born with a complex congenital heart defect (CHD) requiring surgery in the first year of after birth. Several of these operations require the implantation of a full-thickness heart patch; however, the current patch materials available to pediatric heart surgeons are exclusively non-living and non-degradable, which do not grow with the patient and are prone to fail due to an inability to integrate with the heart. In this work, the goal was to develop a full-thickness, tissue engineered myocardial patch (TEMP) that is made from biodegradable components, strong enough to withstand the mechanical forces of the heart wall, and able to integrate with the heart and drive neotissue formation. Here, a thick and porous electrospun PCL sc

SUBMITTER: Jarrell DK 

PROVIDER: S-EPMC10732481 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature