DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I - the impact of inflammation.

ABSTRACT: Mastitis is among the main reasons women cease breastfeeding, which leads to them supplementing breast milk with artificial formula. In farm animals, mastitis results in significant economic losses and the premature culling of some animals. Nevertheless, researchers do not know enough about the effect of inflammation on the mammary gland. This article discusses the changes to DNA methylation in mouse mammary tissue caused by lipopolysaccharide-induced inflammation (4 h post-injection of lipopolysaccharide). We analysed the expression of some genes related to mammary gland function, epigenetic regulation, and the immune response. The analysis focused on three comparisons: inflammation during the first lactation, inflammation during second lactation with no history of inflammation, and infla

SUBMITTER: Ivanova E 

PROVIDER: S-EPMC10732689 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature