Epigenetic Age Acceleration and Chronological Age: Associations With Cognitive Performance in Daily Life.

ABSTRACT: DNA methylation-derived epigenetic clocks offer the opportunity to examine aspects of age acceleration (ie, the difference between an individual's biological age and chronological age), which vary among individuals and may better account for age-related changes in cognitive function than chronological age. Leveraging existing ambulatory cognitive assessments in daily life from a genetically diverse sample of 142 adults in midlife, we examined associations between 5 measures of epigenetic age acceleration and performance on tasks of processing speed and working memory. Covarying for chronological age, we used multilevel models to examine associations of epigenetic age acceleration (Horvath 1, Horvath 2, Hannum, PhenoAge, and GrimAge clocks) with both average level and variability of cogniti

SUBMITTER: Zavala DV 

PROVIDER: S-EPMC10733172 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature