Physical Resilience as a Predictor of Lifespan and Late-Life Health in Genetically Heterogeneous Mice.

ABSTRACT: Dynamic measures of resilience-the ability to resist and recover from a challenge-may be informative of the rate of aging before overt manifestations such as chronic disease, disability, and frailty. From this perspective mid-life resilience may predict longevity and late-life health. To test this hypothesis, we developed simple, reproducible, clinically relevant challenges, and outcome measures of physical resilience that revealed differences between and within age groups of genetically heterogeneous mice, and then examined associations between mid-life resilience and both lifespan and late-life measures of physiological function. We demonstrate that time to recovery from isoflurane anesthesia and weight change following a regimen of chemotherapy significantly differed among young, middle

SUBMITTER: Brown AK 

PROVIDER: S-EPMC10733175 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature