Association of Kidney Function With Dementia and Structural Brain Differences: A Large Population-Based Cohort Study.

ABSTRACT:

Background

The association between kidney function and dementia risk and the mechanisms underlying this relationship remain unclear.

Methods

Within the UK Biobank, 191 970 dementia-free participants aged ≥60 (mean age: 64.1 ± 2.9 years) were followed for 16 years to detect incident dementia. Serum creatinine and Cystatin C were measured at baseline to calculate estimated glomerular filtration rate (eGFR, mL/min/1.73 m2). Kidney function was categorized as normal (eGFR ≥ 90), mildly impaired (60 ≤ eGFR < 90), or moderately to severely impaired (eGFR < 60). Dementia was assessed based on self-reported medical history and medical records. During the follow-up, a subsample of 12 637 participants underwent brain MRI scans. Volumes of total brain, gray matter, white matter, hippoc

SUBMITTER: Wang S 

PROVIDER: S-EPMC10733178 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature