Olfactory Dysfunction and Depression Trajectories in Community-Dwelling Older Adults.

ABSTRACT:

Background

We examined the relationship between baseline olfactory performance and incident significant depressive symptoms and longitudinal depression trajectories in well-functioning older adults. Inflammation and cognitive status were examined as potential mediators.

Methods

Older adults (n = 2 125, 71-82 years, 51% female, 37% Black) completed an odor identification task at Year 3 (our study baseline) of the Health, Aging, and Body Composition study. Cognitive assessments, depressive symptoms, and inflammatory markers were ascertained across multiple visits over 8 years. Discrete-time complementary log-log models, group-based trajectory models, and multivariable-adjusted multinomial logistic regression were employed to assess the relationship between baseline olfaction a

SUBMITTER: Kamath V 

PROVIDER: S-EPMC10733184 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature