Individual response in patient's effort and driving pressure to variations in assistance during pressure support ventilation.

ABSTRACT:

Background

During Pressure Support Ventilation (PSV) an inspiratory hold allows to measure plateau pressure (Pplat), driving pressure (∆P), respiratory system compliance (Crs) and pressure-muscle-index (PMI), an index of inspiratory effort. This study aims [1] to assess systematically how patient's effort (estimated with PMI), ∆P and tidal volume (Vt) change in response to variations in PSV and [2] to confirm the robustness of Crs measurement during PSV.

Methods

18 patients recovering from acute respiratory failure and ventilated by PSV were cross-randomized to four steps of assistance above (+ 3 and + 6 cmH₂O) and below (-3 and -6 cmH₂O) clinically set PS. Inspiratory and expiratory holds were performed to measure Pplat, PMI, ∆P, Vt, Crs, P0.1 and occl

SUBMITTER: Docci M 

PROVIDER: S-EPMC10733248 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature