A unique sigma/anti-sigma system in the actinomycete Actinoplanes missouriensis.

ABSTRACT: Bacteria of the genus Actinoplanes form sporangia that contain dormant sporangiospores which, upon contact with water, release motile spores (zoospores) through a process called sporangium dehiscence. Here, we set out to study the molecular mechanisms behind sporangium dehiscence in Actinoplanes missouriensis and discover a sigma/anti-sigma system with unique features. Protein σ^SsdA contains a functional sigma factor domain and an anti-sigma factor antagonist domain, while protein SipA contains an anti-sigma factor domain and an anti-sigma factor antagonist domain. Remarkably, the two proteins interact with each other via the anti-sigma factor antagonist domain of σ^SsdA and the anti-sigma factor domain of SipA. Although it remains unclear whether the SipA/σ^SsdA</

SUBMITTER: Tezuka T 

PROVIDER: S-EPMC10733313 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature