Adult stem cell activity in naked mole rats for long-term tissue maintenance.

ABSTRACT: The naked mole rat (NMR), Heterocephalus glaber, the longest-living rodent, provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity and tissue function with increasing lifespan. Using cumulative BrdU labelling and a quantitative imaging approach to track intestinal ASCs (Lgr5⁺) in their native in vivo state, we find an expanded pool of Lgr5⁺ cells in NMRs, and these cells specifically at the crypt base (Lgr5^+CBC) exhibit slower division rates compared to those in short-lived mice but have a similar turnover as human LGR5^+CBC cells. Instead of entering quiescence (G0), NMR Lgr5^+CBC cells reduce their division rates by prolonging arrest in the G1 and/or G2 phases of the cell cycle. Moreover, we al

SUBMITTER: Montazid S 

PROVIDER: S-EPMC10733326 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature