Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways.

ABSTRACT: Reproduction is highly dependent on environmental and physiological factors including nutrition, mating stimuli and microbes. Among these factors, microbes facilitate vital functions for host animals such as nutritional intake, metabolic regulation, and enhancing fertility under poor nutrition conditions. However, detailed molecular mechanisms by which microbes control germline maturation, leading to reproduction, remain largely unknown. In this study, we show that environmental microbes exert a beneficial effect on Drosophila oogenesis by promoting germline stem cell (GSC) proliferation and subsequent egg maturation via acceleration of ovarian cell division and suppression of apoptosis. Moreover, insulin-related signaling is not required; rather, the ecdysone pathway is necessary for micr

SUBMITTER: Suyama R 

PROVIDER: S-EPMC10733356 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature