Myricetin suppresses traumatic brain injury-induced inflammatory response via EGFR/AKT/STAT pathway.

ABSTRACT: Traumatic brain injury (TBI) is a common disease in neurosurgery with a high fatality and disability rate which imposes a huge burden on society and patient's family. Inhibition of neuroinflammation caused by microglia activation is a reasonable strategy to promote neurological recovery after TBI. Myricetin is a natural flavonoid that has shown good therapeutic effects in a variety of neurological disease models, but its therapeutic effect on TBI is not clear. We demonstrated that intraperitoneal injection of appropriate doses of myricetin significantly improved recovery of neurological function after TBI in Sprague Dawley rats and inhibited excessive inflammatory responses around the lesion site. Myricetin dramatically reduced the expression of toxic microglia markers generated by TBI and

SUBMITTER: Wang C 

PROVIDER: S-EPMC10733425 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature