Impact of endocrine dysregulation on disability and non-motor symptoms in pediatric onset multiple sclerosis.

ABSTRACT:

Background

Pediatric onset multiple sclerosis (POMS) commonly occurs at the time of various endocrine changes. Evaluation of the impact of endocrine status on disease severity in POMS has not been previously explored.

Objective

This study sought to evaluate if sex and stress hormones in children with POMS impact motor and non-motor diseases severity.

Methods

A single-center case control study was performed. Individuals with POMS were compared to individuals without neurologic disease. Each individual had three blood draws assessing stress and sex hormones between 07:00 and 09:00. Measures of fatigue (Epworth sleepiness scale), depression (PHQ-9), and quality of life (PedsQL) assessed at each visit.

Results

Forty individuals with POMS and 40 controls were enroll

SUBMITTER: Abe J 

PROVIDER: S-EPMC10733457 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature