Proteomic signature profiling in the cortex of dairy cattle unravels the physiology of brain aging.

ABSTRACT:

Introduction

Aging is a physiological process occurring in all living organisms. It is characterized by a progressive deterioration of the physiological and cognitive functions of the organism, accompanied by a gradual impairment of mechanisms involved in the regulation of tissue and organ homeostasis, thus exacerbating the risk of developing pathologies, including cancer and neurodegenerative disorders.

Methods

In the present work, for the first time, the influence of aging has been investigated in the brain cortex of the Podolica cattle breed, through LC-MS/MS-based differential proteomics and the bioinformatic analysis approach (data are available via ProteomeXchange with identifier PXD044108), with the aim of identifying potential aging or longevity markers, also associa

SUBMITTER: Cozzolino F 

PROVIDER: S-EPMC10733460 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature