Comparative analysis of contemporary anti-double stranded DNA antibody assays for systemic lupus erythematosus.

ABSTRACT:

Objective

Elevated double-stranded DNA (dsDNA) antibody levels in blood serum are considered a disease-specific marker in systemic lupus erythematosus (SLE), correlate with disease activity and the incidence of lupus nephritis, and can be detected in up to 86% of all SLE cases. Despite the high clinical relevance, the variety of dsDNA antibody testing methods with heterogenous performance in clinical use remains challenging. This study is the first to prospectively investigate the performance of two of today's most commonly applied anti-dsDNA testing methods head-to-head under real-world conditions, as well as their correlation with other clinical and serological disease parameters in SLE patients.

Methods

In this prospective study, all SLE patients undergoing treatment at t

SUBMITTER: Bauer CJ 

PROVIDER: S-EPMC10733465 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature