Bioinformatics-led discovery of liver-specific genes and macrophage infiltration in acute liver injury.

ABSTRACT:

Background

Acute liver injury (ALI) is an important global health concern, primarily caused by widespread hepatocyte cell death, coupled with a complex immune response and a lack of effective remedies. This study explores the underlying mechanisms, immune infiltration patterns, and potential targets for intervention and treatment ALI.

Methods

The datasets of acetaminophen (APAP), carbon tetrachloride (CCl4), and lipopolysaccharide (LPS)-induced ALI were obtained from the GEO database. Differentially expressed genes (DEGs) were individually identified using the limma packages. Functional enrichment analysis was performed using KEGG, GO, and GSEA methods. The overlapping genes were extracted from the three datasets, and hub genes were identified using MCODE and CytoHubba algor

SUBMITTER: Cao Z 

PROVIDER: S-EPMC10733525 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature