Giant-cell arteritis related strokes: scoping review of mechanisms and rethinking treatment strategy?

ABSTRACT: Stroke is a rare and severe complication of giant cell arteritis (GCA). Although early diagnosis and treatment initiation are essential, the mechanism of stroke is often related to vasculitis complicated by arterial stenosis and occlusion. Its recurrence is often attributed to early steroid resistance or late GCA relapse, so immunosuppressive treatment is often reinforced. However, many questions concerning the mechanisms of stroke remain elusive, and no review to date has examined the whole data set concerning GCA-related stroke. We therefore undertook this scoping review. GCA-related stroke does not necessarily display general signs and inflammatory parameters are sometimes normal, so clinicians should observe caution. Ischemic lesions often show patterns predating watershed areas and ar

SUBMITTER: Bonnan M 

PROVIDER: S-EPMC10733536 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature