Photodynamic Therapy Minimally Affects HEMA-DMAEMA Hydrogel Viscoelasticity.

ABSTRACT: Soft matter implants are a rapidly growing field in medicine for reconstructive surgery, aesthetic treatments, and regenerative medicine. Though these procedures are efficacious, all implants carry risks associated with microbial infection which are often aggressive. Preventative and responsive measures exist but are limited in applicability to soft materials. Photodynamic therapy (PDT) presents a means to perform safe and effective antimicrobial treatments in proximity to soft implants. HEMA-DMAEMA hydrogels are prepared with the photosensitizer methylene blue included at 10 and 100 µM in solution used for swelling over 2 or 4 days. Thirty minutes or 5 h of LED illumination at 9.20mWcm2$9.20\frac{{mW}}{{c{m}^2}}$ is then used for PDT-induced generation of reactive oxygen species in direct

SUBMITTER: Willis JA 

PROVIDER: S-EPMC10733547 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature