Testing associations between human anxiety and genes previously implicated by mouse anxiety models.

ABSTRACT: Anxiety disorders are common and can be debilitating, with effective treatments remaining hampered by an incomplete understanding of the underlying genetic etiology. Improvements have been made in understanding the genetic influences on mouse behavioral models of anxiety, yet it is unclear the extent to which genes identified in these experimental systems contribute to genetic variation in human anxiety phenotypes. Leveraging new and existing large-scale human genome-wide association studies, we tested whether sets of genes previously identified in mouse anxiety-like behavior studies contribute to a range of human anxiety disorders. When tested as individual genes, 13 mouse-identified genes were associated with human anxiety phenotypes, suggesting an overlap of individual genes contributin

SUBMITTER: Brasher MS 

PROVIDER: S-EPMC10733569 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature