Molecular Detection of Secreted Aspartyl Proteinases (Saps) From Dental Isolates of Candida albicans and Targeting With Psidium guajava Biocompounds: An In Vitro and In Silico Analysis.

ABSTRACT: Introduction Candida albicans (C. albicans) is an opportunistic yeast-like fungus and is considered a functional biome of the oral and gut microbiomes. The sap gene and its types play a vital role in the pathogenesis of C. albicans. The emergence of resistance traits is a major problem, and targeting the same with alternative medicines has sparked renewed interest in recent years. Objectives This study is thus aimed at detecting the frequency of sap gene types in the clinical isolates of C. albicans and evaluating the antifungal effect of the crude methanolic extract of Psidium guajava (P. guajava). Further in silico assessments will assess the inhibitory effect of six compounds of P. guajava against the Sap protein. Materials

SUBMITTER: Safiya S N 

PROVIDER: S-EPMC10733579 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature