Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period.

ABSTRACT: Genetic factors contribute significantly to interindividual differences in the susceptibility to stress-related disorders. As stress can also be conceptualized as environmental exposure, controlled gene-environment interaction (GxE) studies with an in-depth phenotyping may help to unravel mechanisms underlying the interplay between genetic factors and stress. In a prospective-longitudinal quasi-experimental study, we investigated whether polygenic scores (PGS) for depression (DEP-PGS) and neuroticism (NEU-PGS), respectively, were associated with responses to chronic stress in daily life. We examined law students (n = 432) over 13 months. Participants in the stress group experienced a long-lasting stress phase, namely the preparation for the first state examination for law students. The con

SUBMITTER: Peter HL 

PROVIDER: S-EPMC10733580 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature