Identification of eczema clusters and their association with filaggrin and atopic comorbidities: analysis of five birth cohorts.

ABSTRACT:

Background

Longitudinal modelling of the presence/absence of current eczema through childhood has identified similar phenotypes, but their characteristics often differ between studies.

Objectives

To demonstrate that a more comprehensive description of longitudinal pattern of symptoms may better describe trajectories than binary information on eczema presence.

Methods

We derived six multidimensional variables of eczema spells from birth to 18 years of age (including duration, temporal sequencing and the extent of persistence/recurrence). Spells were defined as consecutive observations of eczema separated by no eczema across 5 epochs in five birth cohorts: infancy (first year); early childhood (age 2-3 years); preschool/early school age (4-5 years); middle childhood (8-

SUBMITTER: Haider S 

PROVIDER: S-EPMC10733627 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature