Duloxetine plus exercise for knee osteoarthritis and depression: A feasibility study.

ABSTRACT:

Objective

To assess the feasibility of a 24-week, center-based, aerobic exercise program plus duloxetine to treat symptomatic knee osteoarthritis (OA) and major depression.

Design

Patients with symptomatic knee OA and major depression were recruited between August 2021 and November 2022 from the University of Maryland and VA Maryland Health Care Systems and Baltimore metropolitan area using medical records and advertisements. The intervention included 1) supervised treadmill walking 3 times weekly and 2) duloxetine starting at 30 ​mg each day and titrating up to the optimal dosage of 60 ​mg daily. Data collection occurred at baseline and 12- and 24-weeks follow-up. Feasibility was evaluated from recruitment rates, reasons for drop out, and treatment adherence. Clinical measu

SUBMITTER: Rathbun AM 

PROVIDER: S-EPMC10733673 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature