Pathological and virological findings of type I interferon receptor knockout mice upon experimental infection with Heartland virus.

ABSTRACT: Heartland virus (HRTV) causes generalized symptoms, severe shock, and multiple organ failure. We previously reported that interferon-α/β receptor knockout (IFNAR^-/-) mice infected intraperitoneally with 1 × 10⁷ tissue culture-infective dose (TCID₅₀) of HRTV died, while those subcutaneously infected with the same dose of HRTV did not. The pathophysiology of IFNAR^-/- mice infected with HRTV and the mechanism underlying the difference in disease severity, which depends on HRTV infection route, were analyzed in this study. The liver, spleen, mesenteric and axillary lymph nodes, and gastrointestinal tract of intraperitoneally (I.P.) infected mice had pathological changes; however, subcutaneously (S.C.) infec

SUBMITTER: Fujii H 

PROVIDER: S-EPMC10733679 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature