Endoplasmic Reticulum Calcium Mediates Drosophila Wing Development.

ABSTRACT:

Background

The temporal dynamics of morphogen presentation impacts transcriptional responses and tissue patterning. However, the mechanisms controlling morphogen release are far from clear. We found that inwardly rectifying potassium (Irk) channels regulate endogenous transient increases in intracellular calcium and bone morphogenetic protein (BMP/Dpp) release for Drosophila wing development. Inhibition of Irk channels reduces BMP/Dpp signaling, and ultimately disrupts wing morphology. Ion channels impact development of several tissues and organisms in which BMP signaling is essential. In neurons and pancreatic beta cells, Irk channels modulate membrane potential to affect intracellular Ca⁺⁺ to control secretion of neurotransmitters and insulin. Based on Irk activ

SUBMITTER: George LF 

PROVIDER: S-EPMC10733776 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature