Patient-Reported Outcome Measures for Severe Recurrent Bilateral Nasal Polyps: Psychometric Evaluation and Content Validity.

ABSTRACT:

Objective

To date, no patient-reported outcome measures have been specifically developed to assess pharmacological treatment effect in participants with severe chronic rhinosinusitis (CRS) with recurrent bilateral nasal polyps (NP). These studies aimed to assess (1) the psychometric properties and (2) content validity of Visual Analogue Scales (VAS) assessing NP symptom severity.

Study design

(1) Retrospective psychometric validation study using clinical trial data and (2) cross-sectional qualitative patient interview study.

Setting

(1) Multicentre trial; (2) real-world.

Methods

(1) Psychometric validation was performed using data from a randomized, double-blind, placebo-controlled, Phase II study (NCT01362244) investigating the effect of mepolizumab in 105 par

SUBMITTER: Gater A 

PROVIDER: S-EPMC10733778 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature