Separating Measurement Error and Signal in Environmental Data: Use of Replicates to Address Uncertainty.

ABSTRACT: Measurement uncertainty has long been a concern in the characterizing and interpreting environmental and toxicological measurements. We compared statistical analysis approaches when there are replicates: a Naı̈ve approach that omits replicates, a Hybrid approach that inappropriately treats replicates as independent samples, and a Measurement Error Model (MEM) approach in a random effects analysis of variance (ANOVA) model that appropriately incorporates replicates. A simulation study assessed the effects of sample size and levels of replication, signal variance, and measurement error on estimates from the three statistical approaches. MEM results were superior overall with confidence intervals for the observed mean narrower on average than those from the Naı̈ve approach, giving improved ch

SUBMITTER: Furman M 

PROVIDER: S-EPMC10733784 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature