Can polygenic risk scores help identify pediatric bipolar spectrum and related disorders?: A systematic review.

ABSTRACT: The genetic basis of mood disorders can, theoretically, provide diagnostic information in scenarios of clinical uncertainty. Therefore, we examined the available body of knowledge on the association between polygenic risk scores for bipolar disorder (BP-PRSs) and pediatric bipolar spectrum and related disorders. We performed a literature search through PubMed in March of 2020. The following variables were extracted from relevant studies: population age, study sample size, source of polygenic risk scores, source of data, the primary goal of the study, the assessments used during the course of the study, and the main findings/outcomes of each study. BP-PRSs were associated with deficits in executive functioning and the diagnosis of attention deficit/hyperactivity disorder (ADHD). Three studi

SUBMITTER: Biederman J 

PROVIDER: S-EPMC10733908 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature