Inhibitory input directs astrocyte morphogenesis through glial GABA_BR.

ABSTRACT: Communication between neurons and glia has an important role in establishing and maintaining higher-order brain function¹. Astrocytes are endowed with complex morphologies, placing their peripheral processes in close proximity to neuronal synapses and directly contributing to their regulation of brain circuits^2-4. Recent studies have shown that excitatory neuronal activity promotes oligodendrocyte differentiation^5-7; whether inhibitory neurotransmission regulates astrocyte morphogenesis during development is unclear. Here we show that inhibitory neuron activity is necessary and sufficient for astrocyte morphogenesis. We found that input from inhibitory neurons functions through astrocytic GABA_B receptor (GABA_BR) and that its deletion i

SUBMITTER: Cheng YT 

PROVIDER: S-EPMC10733939 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature