Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors.

ABSTRACT: Inflammation in the intestines causes abdominal pain that is challenging to manage. The terminals of sensory neurons innervating the gut are surrounded by glia. Here, using a mouse model of acute colitis, we found that enteric glia contribute to visceral pain by secreting factors that sensitized sensory nerves innervating the gut in response to inflammation. Acute colitis induced a transient increase in the production of proinflammatory cytokines in the intestines of male and female mice. Of these, IL-1β was produced in part by glia and augmented the opening of the intercellular communication hemichannel connexin-43 in glia, which made normally innocuous stimuli painful in female mice. Chemogenetic glial activation paired with calcium imaging in nerve terminals demonstrated that glia sensi

SUBMITTER: Morales-Soto W 

PROVIDER: S-EPMC10733972 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature