Associations of phthalates, phthalate replacements, and their mixtures with eicosanoid biomarkers during pregnancy.

ABSTRACT: Humans are exposed to complex mixtures of phthalates. Gestational exposure to phthalates has been linked to preeclampsia and preterm birth through potential pathways such as endocrine disruption, oxidative stress, and inflammation. Eicosanoids are bioactive signaling lipids that are related to a variety of homeostatic and inflammatory processes. We investigated associations between urinary phthalates and their mixtures with plasma eicosanoid levels during pregnancy using the PROTECT cohort in Puerto Rico (N = 655). After adjusting for covariates, we estimated pair-wise associations between the geometric mean of individual phthalate metabolite concentrations across pregnancy and eicosanoid biomarkers using multivariable linear regression. We used bootstrapping of adaptive elastic net regres

SUBMITTER: Park S 

PROVIDER: S-EPMC10733973 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature