Continuous Synthesis of Carbamates from CO₂ and Amines.

ABSTRACT: We present a novel approach for the continuous preparation of carbamates. The simple yet fast synthetic route relies on directly utilizing carbon dioxide and, in contrast with the literature-known methods, only employs 1,8-diazabicyclo[5.4.0]undec-7-ene as an additive. The applicable amines' diversity offers considerable flexibility to the synthetic protocol. Additionally, the continuous method's applicability significantly decreases the reaction time typically required for CO₂-based carbamate synthesis and allows for straightforward and precise gas introduction. The mild reaction conditions and omission of the need for column chromatography render the process less time-demanding and environmentally more benign, providing the desired compounds in yields of 45 to 92%. Moreover, t

SUBMITTER: Stagel K 

PROVIDER: S-EPMC10734002 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature