Relationship between thyroid-stimulating hormone, BDNF levels, and hippocampal volume in antipsychotic-naive first-episode psychosis patients.

ABSTRACT:

Introduction

Thyroid hormones play an essential role in hippocampal development, a key structure in psychosis. However, the role of these hormones in first-episode psychosis (FEP) has received limited attention. It has been hypothesized that thyroid hormones could cause morphological modifications in the hippocampal structure through the upregulation of brain-derived neurotrophic factor (BDNF). In this study, we primarily aimed to determine the relationship between thyroid-stimulating hormone (TSH) levels, peripheral BDNF levels, and hippocampal volume in antipsychotic-naïve FEP patients. We also aimed to determine whether TSH levels were associated with clinical symptomatology.

Materials and methods

A total of 50 antipsychotic-naïve FEP patients were included in the study.

SUBMITTER: Toll A 

PROVIDER: S-EPMC10734033 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature