Primary aldosteronism and lower-extremity arterial disease: a two-sample Mendelian randomization study.

ABSTRACT:

Background and aims

Primary aldosteronism (PA) is an adrenal disorder of autonomous aldosterone secretion which promotes arterial injury. We aimed to explore whether PA is causally associated with lower-extremity arterial disease (LEAD).

Methods

We included 39,713 patients with diabetes and 419,312 participants without diabetes from UK Biobank. We derived a polygenic risk score (PRS) for PA based on previous genome-wide association studies (GWAS). Outcomes included LEAD and LEAD related gangrene or amputation. We conducted a two-sample Mendelian randomization analysis for PA and outcomes to explore their potential causal relationship.

Results

In whole population, individuals with a higher PA PRS had an increased risk of LEAD. Among patients with diabetes, compared to

SUBMITTER: Hu J 

PROVIDER: S-EPMC10734059 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature