Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms.

ABSTRACT:

Background

Cadherins are calcium-dependent transmembrane cell-cell adhesion proteins that are essential for metazoan development. They consist of three subfamilies: classical cadherins, which bind catenin, protocadherins, which contain 6-7 calcium-binding repeat domains, and atypical cadherins. Their functions include forming adherens junctions, establishing planar cell polarity (PCP), and regulating cell shape, proliferation, and migration. Because they are basal deuterostomes, echinoderms provide important insights into bilaterian evolution, but their only well-characterized cadherin is G-cadherin, a classical cadherin that is expressed by many embryonic epithelia. We aimed to better characterize echinoderm cadherins by conducting phylogenetic analyses and examining the spatiotem

SUBMITTER: Chess MM 

PROVIDER: S-EPMC10734073 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature