A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy.

ABSTRACT: Photothermal therapy (PTT) and photodynamic therapy (PDT) are effective method for tumor treatment. However, the limited variety and quantity of photothermal agents (PTAs) and photosensitizer (PSs) are still major challenges. Moreover, the cell apoptosis mechanism induced by PDT and PTT is still elusive. A fused-ring small molecule acceptor-donor acceptor' donor-acceptor (A-DA'D-A) type of Y5 (Scheme 1) has a narrow band-gap and strong light absorption. Herein, we used Y5 to polymerize with thiophene unit to obtain polymer PYT based on polymerized small molecule strategy, and PYT nanoparticles (PYT NPs) was prepared via one-step nanoprecipitation strategy with DSPE-PEG₂₀₀₀. PYT NPs had excellent biocompatibility, good photostability, high photothermal conversion efficiency (67%)

SUBMITTER: Xie X 

PROVIDER: S-EPMC10734082 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature